2 edition of Material properties, and in vitro and in vivo degradation of calcium polyphosphate. found in the catalog.
Material properties, and in vitro and in vivo degradation of calcium polyphosphate.
Sidney Jennifer Omelon
Written in English
The reduction in strength was mitigated if the structure was dissolved in cell culture media supplemented with proteins instead of deionized water. The reduction in mechanical properties for the wet, partially-dissolved, crystalline CPP was not as great as for the semi-crystalline CPP.Osteoarthritis is a mobility-impairing and painful joint disease with no known cure. A promising remedial technology is the development of an osteochontral implant that presents tissue-engineered cartilage on one face, and a porous, inorganic supporting structure composed of calcium polyphosphate on the other. Once implanted in an osteochondral defect, the ideal supporting structure dissolves at the same rate as bone in-growth, re-creating the bone-cartilage interface.Calcium polyphosphate (CPP) is a unique ceramic composed of calcium and polyphosphate ions. Polyphosphate ions are polymers of phosphate ions linked together with P-O-P bonds. Polyphosphate polymers allow CPP to exist as a glass, crystalline solid, or semi-crystalline (part glass, part crystalline) solid. Divalent calcium ions allow CPP glass to transform into a hydrogel when exposed to aqueous solutions because strong cross-links can form between calcium and polyphosphate ions.In this thesis, the structure, mechanical properties and degradation of two groups of porous CPP sintered at different temperatures were examined. A semi-crystalline CPP resulted from sintering at a lower temperature. This semi-crystalline CPP dissolves more rapidly than CPP with a higher crystalline content because amorphous CPP forms a hydrogel and dissolves more rapidly than crystalline CPP.It is proposed that the ionic bonds that form between polyphosphate and calcium ions may delay new bone mineralization. Elevated in vivo concentrations of polyphosphate released from semi-crystalline CPP were co-located with unmineralized bone tissue. This suggests that a semi-crystalline CPP implant may delay mineralization of local new bone.The mechanical properties of as-sintered and CPP structures partially dissolved in deionized water or cell culture media were characterized with Weibull parameters. The characteristic strength and Weibull modulus were both reduced by partial dissolution of the semi-crystalline CPP structure. The reduction was larger if the sample was wet when tested. A wet sample contains weak hydrogel that can dry into a stronger glass.
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The capacity of calcium phosphates to be replaced by bone is tightly linked to their resorbability. However, the relative importance of some textural parameters on their degradation behavior is still unclear. The present study aims to quantify the effect of composition, specific surface area (SSA), and porosity at various length scales (nano-, micro- and macroporosity) on the in vitro Cited by: This paper describes a comparative investigation into the in vitro solubility of the calcium polyphosphates, γ-Ca(PO3)2 and β-Ca(PO3)2. The differing arrangement of their polyphosphates chains appears to result in significant dissolution of γ-Ca(PO3)2 polymorph over the β-Ca(PO3)2 polymorph, which exhibits limited dissolution. These properties are discussed with respect to structure and Cited by: 1.
In vitro studies indicate that it does not alter the physicochemical and biological properties of the mineral phase. MHPC is not intended to produce a high-strength material in vivo, in the manner of PMMA or a calcium phosphate cement (SRS Norian), but to create a matrix for deep cell colonization providing intense by: This study is conducted to investigate the biocompatibility and biodegradation behavior of calcium phosphate-coated Mg alloy in m phosphate (Ca–P) was coated on the Mg alloy (AZ31) by a chemical by:
Monetite and brushite coated magnesium: in vivo and in vitro models for degradation analysis 1 October | Journal of Materials Science: Materials in Medicine, Vol. 25, No. 1 Ready-to-use injectable calcium phosphate bone cement paste as drug carrierCited by: METHODS:The novel scaffold was characterized by XRD, FTIR and SEM. The porosity, cell mediated degradation behavior and mechanical properties were also investigated. Meanwhile, cell proliferation activity and adhesion in vitro was exploited. Finally, osteogenesis the LiCPP scaffolds in vitro and in vivo was by: 1.
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The in vitro degradation results demonstrated that the PLGA/CPC scaffold had good degradability. The degradation of PLGA film on the surface of the scaffold made the CPC matrix exposed, which facilitated cell response and by: Calcium phosphate (CaP) was electrochemically coated on a magnesium–calcium (Mg–Ca) alloy using an unconventional electrolyte and a pulse-potential method.
The CaP particles of the coating were relatively large, flat, and irregularly oriented; however, they covered the entire alloy surface with a coating thickness of 5 μm.
Cytocompatibility tests using L cells inoculated in Eagle Cited by: The present study aims to quantify the effect of composition, specific surface area (SSA), and porosity at various length scales (nano- micro- and macroporosity) on the in vitro degradation of different calcium phosphates.
Degradation studies were performed in an Cited by: In Vitro Degradation Studies of Calcium Polyphosphate Ceramics Prepared by Controlled Degree of Polymerization and Crystallization p Rheological Properties and Injectability of a Calcium Phosphate Bone Substitute MaterialCited by: Calcium polyphosphate is a novel synthetic scaffold material that has shown good mechanical properties and biocompatibility.
Here, we evaluated calcium polyphosphate in terms of its ability to support cell proliferation and differentiation in by: 9. In Vitro and In Vivo Evaluation of Starfish Bone-Derived β-Tricalcium Phosphate as a Bone Substitute Material by Haruka Ishida 1,2, Hisao Haniu 1,2,3,*, Akari Takeuchi 2,3, Katsuya Ueda 1,2, Mahoko Sano 1,3, Manabu Tanaka 4, Takashi Takizawa 4, Atsushi Sobajima 4, Takayuki Kamanaka 4 and Naoto Saito 1,2,3Author: Haruka Ishida, Hisao Haniu, Akari Takeuchi, Katsuya Ueda, Mahoko Sano, Manabu Tanaka, Takashi Takiza.
In vivo evaluation of calcium polyphosphate for bone regeneration Article in Journal of Biomaterials Applications 27(3) September with 20 Reads How we measure 'reads'. In this study composites of calcium phosphate cements with incorporated PLGA, gelatin or PTMC microspheres were implanted subcutaneously into the backs of rabbits to investigate the in vivo degradation characteristics and to evaluate the biocompatibility of these materials.
For in vitro degradation studies with microsphere/CPC composites macroporosity was generated by various Cited by: An important design criterion for bone substitutes is their ability to biodegrade, as they must be replaced by bone following implantation.
In vitro studies have identified that the CPP degradation products are polyphosphate, calcium and phosphate. These are likely generated by hydrolysis of the polyphosphate chains forming the bone substitute; however, cell-regulated dissolution is also by: Youxin Hu, Robert Pilliar, Marc Grynpas, Rita Kandel, Ulrike Werner-Zwanziger and Mark Filiaggi, Phase transformations during processing and in vitro degradation of porous calcium polyphosphates, Journal of Materials Science: Materials in Medicine, /s, 27, 7, ().Cited by: 6.
In Vivo Degradation and Resorption of Calcium Phosphates For clarity, the term “degradation” represents the physical process of disintegration and fragmentation, whereas, the term “resorption” essentially signiﬁes biodegradation taking place via cellular mechanisms.
Biodegradation of CaP based biomaterial is thought to take place viaFile Size: 2MB. O-phospho-L-serine modified calcium phosphate cements - Material properties, in vitro and in vivo investigations Article in Materialwissenschaft und Werkstofftechnik 37(6) - June The microstructure, mechanical properties and degradation behavior in physiological saline of the composites were investigated.
The obtained results show that ultrafine calcium polyphosphate particles uniformly distribute in the ZK60A matrices without voids for the composites containing and 5 wt.% calcium by: Preparation, characterization and in vitro study of a series of calcium polyphosphate (CPP) with different polymerization degree were reported.
A series of CPP with different polymerization degree were prepared by controlling calcining time. Average polymerization degree was analyzed by liquid state 31 P nuclear magnetic resonance (NMR).
The Cited by: The in vitro and in vivo degradation behavior and biocompatibility of Mg–2Sr–Ca and Mg–2Sr–Zn alloys were investigated. The following conclusions can be drawn: 1. The in vitro degradation rates of Mg–2Sr–Ca and Mg–2Sr–Zn alloys are mm/yr and mm/yr, which is about % and % of the as-rolled Mg–2Sr alloys.
The Author: Kai Chen, Xinhui Xie, Xinhui Xie, Hongyan Tang, Hui Sun, Ling Qin, Yufeng Zheng, Xuenan Gu, Yubo Fan. Phase transformations during processing and in vitro degradation of porous calcium polyphosphates Article (PDF Available) in Journal of Materials Science Materials in Medicine 27(7) July Also, the capability of Sr-doped calcium polyphosphate (SCPP) to stimulate angiogenic and osteogenic processes was analyzed in vitro and in vivo by Gu et al.
They used an in vitro co-cultured model of human umbilical vein endothelial cells (HUVECs) and osteoblasts and then cultured the cells with SCPP, calcium polyphosphate (CPP), and HA Author: Radu Albulescu, Adrian-Claudiu Popa, Ana-Maria Enciu, Lucian Albulescu, Maria Dudau, Ionela Daniela.
Keywords: calcium polyphosphate, degradation, mathematical model 1. Introduction Controlling degradation behavior is a critical property in bone repair materials research, and has been widely investigated to date1. In general, the degradation of the biomaterial should be controlled precisely to give enough time for the cells to lay down their.
Material properties, and in vitro and in vivo degradation of calcium polyphosphate Sj Omelon Fundamentals of materials science and engineering: an interactive e-text. 1 In vitro degradation of calcium phosphates: effect of multiscale porosity, textural properties and composition A.
Díez-Escudero 1,2, M. Espanol,2, S. Beats1,2, M.P. Ginebra1,2,3 1 Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgical Engineering, Universitat Politècnica de Catalunya (UPC), Av.
(HA), β-tricalcium phosphate (β-TCP), and calcium polyphosphate [3,4,6,7]. The biodegradation behavior of calcium polyphosphate materials in both in vitro and in vivo has been reported .
Utilizing solid freeform fabrication to build porous parts of calcium polyphosphate, Porter et al. Cited by: 8.Calcium phosphate ceramic materials are extensively used for bone replacement and regeneration in orthopedic, dental, and maxillofacial surgical applications.
In order for these biomaterials to work effectively it is imperative that they undergo the process of degradation and resorption in vivo. This allows for the space to be created for the new bone tissue to form and infiltrate within the Cited by: ABSTRACT.
In this work, the degradation kinetics of calcium polyphosphate bioceramic was studied. Liquid state 31 P nuclear magnetic resonance (NMR), X-ray diffraction (XRD) and scanning electron microscope (SEM) were used to characterize the product.
The in vitro degradation test was carried out at 37 ºC for up to 48 hours for both the simulation solution and the extreme solution.